ORPHA:79086
Acquired generalized lipodystrophy
Also called Acquired lipoatrophic diabetes, Lawrence syndrome, Lawrence-Seip syndrome
- Body system
- Skin diseases
- Inheritance pattern
- Not applicable
- Typical age of onset
- All ages
- Estimated prevalence
- Unknown (Worldwide)
- Rarity class
- Unknown
About this disease
A rare lipodystrophic syndrome characterized by loss of adipose tissue, and is a syndrome of insulin resistance that leads to increased cardiovascular risk. Acquired generalized lipodystrophy is related to a selective loss of subcutaneous adipose tissue occurring exclusively at the extremities (face, legs, arms, palms and sometimes soles).
Definition from Orphanet.
Common signs
- Hyperinsulinemia
- Insulin resistance
- Insulin-resistant diabetes mellitus
- Hepatic steatosis
- Cardiomyopathy
- Autoimmunity
Learn more
Source: Orphanet (Orphadata), ORPHA:79086. Data release 2026-06-23. www.orphadata.com — CC BY 4.0.