ORPHA:2500
Acrogeria
Also called Acrogeria, Gottron type, Acrometageria, Gottron syndrome
- Body system
- Skin diseases
- Inheritance pattern
- Unknown
- Typical age of onset
- Childhood, Infancy
- Estimated prevalence
- <1 / 1 000 000 (Worldwide)
- Rarity class
- <1 / 1 000 000
About this disease
A rare premature aging syndrome characterized by atrophy of the skin and subcutaneous tissue involving predominantly the distal parts of the extremities, resulting in prematurely aged appearance of the hand and feet. Another prominent feature is the characteristic facies with hollow cheeks, beaked nose, and owl-like eyes. Additional, non-dermatological manifestations, like bone anomalies have been described in some patients. Mode of inheritance has not been definitively established.
Definition from Orphanet.
Common signs
- Joint hypermobility
- Abnormality of the skin
- Thin skin
- Fine hair
- Short stature
- Irregular hyperpigmentation
Learn more
Source: Orphanet (Orphadata), ORPHA:2500. Data release 2026-06-23. www.orphadata.com — CC BY 4.0.