Rare Zebra

Rare disease search prototype built on Orphanet data

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ORPHA:58

Alexander disease

Also called AxD

Body system
Neurological diseases
Inheritance pattern
Autosomal dominant
Typical age of onset
All ages
Estimated prevalence
<1 / 1 000 000 (Japan)
Rarity class
<1 / 1 000 000

ORPHA:58 is classified under "Neurological diseases" in the Orphanet nomenclature.

Common signs

  • Macrocephaly
  • Intellectual disability
  • Seizure
  • Spasticity
  • Agenesis of corpus callosum
  • Hyperreflexia