Rare Zebra

Rare disease search prototype built on Orphanet data

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ORPHA:1465

Coffin-Siris syndrome

Also called CSS

Body system
Bone diseases
Inheritance pattern
Autosomal dominant
Typical age of onset
Antenatal, Neonatal
Estimated prevalence
<1 / 1 000 000 (Worldwide)
Rarity class
<1 / 1 000 000

ORPHA:1465 is classified under "Bone diseases" in the Orphanet nomenclature.

Common signs

  • Prominent eyelashes
  • Feeding difficulties
  • Wide mouth
  • Thick lower lip vermilion
  • Coarse facial features
  • Thick eyebrow