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Rare disease search prototype built on Orphanet data

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ORPHA:661

Congenital central hypoventilation syndrome

Also called Ondine curse, Ondine syndrome, CCHS, Congenital central alveolar hypoventilation syndrome

Body system
Neurological diseases
Inheritance pattern
Autosomal dominant, Not applicable
Typical age of onset
Infancy, Neonatal
Estimated prevalence
1-9 / 1 000 000 (France)
Rarity class
1-9 / 1 000 000

ORPHA:661 is classified under "Neurological diseases" in the Orphanet nomenclature.

Common signs

  • Respiratory insufficiency
  • Abnormality of the autonomic nervous system
  • Seizure
  • Hypotonia
  • Aganglionic megacolon
  • Ganglioneuroma