Rare Zebra

Rare disease search prototype built on Orphanet data

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ORPHA:1336

Hyperkeratosis-hyperpigmentation syndrome

Body system
Skin diseases
Inheritance pattern
Autosomal dominant
Typical age of onset
Adolescent, Childhood, Infancy
Estimated prevalence
<1 / 1 000 000 (Worldwide)
Rarity class
<1 / 1 000 000

ORPHA:1336 is classified under "Skin diseases" in the Orphanet nomenclature.

Common signs

  • Hyperkeratosis
  • Irregular hyperpigmentation
  • Papule
  • Cutaneous photosensitivity
  • Multiple cafe-au-lait spots