Rare Zebra

Rare disease search prototype built on Orphanet data

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ORPHA:441

Pure autonomic failure

Also called Bradbury-Eggleston syndrome, Idiopathic orthostatic hypotension, PAF, Pure dysautonomia, Pure idiopatic dysautonomia

Body system
Neurological diseases
Inheritance pattern
Not applicable
Typical age of onset
Adult, Elderly
Estimated prevalence
1-9 / 1 000 000 (Europe)
Rarity class
1-9 / 1 000 000

ORPHA:441 is classified under "Neurological diseases" in the Orphanet nomenclature.

Common signs

  • Anhidrosis
  • Orthostatic hypotension
  • Abnormality of circulating catecholamine level
  • Abnormal autonomic nervous system physiology
  • Constitutional symptom
  • Urinary incontinence